FACTS ABOUT NR1-SITE REVEALED

Utilizing this method, Kalbaugh et al. assigned affinity and efficacy roles to positions while in the LBDs in the NR1 and NR2A NMDAR subunits. In situ mutation of residues in direct contact with certain ligand afflicted both of those efficacy and affinity, although positions that stabilize the shut cleft conformation with no direct ligand interacti